abstract：:We describe two young men with cystic pituitary enlargement on magnetic resonance imaging (MRI) causing hypopituitarism. The first patient presented acutely unwell with headache and vomiting associated with anterior and posterior pituitary dysfunction. The second patient presented with hypopituitarism after a long his...

journal_title：Pituitary

authors： Burt MG,Morey AL,Turner JJ,Pell M,Sheehy JP,Ho KK

更新日期：2003-01-01 00:00:00

abstract：:In order to explore the presence of, and the potential role of, secretagogin in human pituitary adenomas, an analytical strategy that integrated comparative proteomics and comparative transcriptomics was used to detect the protein and the mRNA expression, respectively, of secretagogin in human non-functional pituitary...

journal_title：Pituitary

authors： Zhan X,Evans CO,Oyesiku NM,Desiderio DM

更新日期：2003-01-01 00:00:00

abstract：:The morphology of the various pituitary cell types is highly dynamic and allows recognition of many cellular functions. Most pituitary cells show morphologic changes that reflect stimulation or inhibition by hormones. Drugs have also been shown to alter the morphology of several pituitary tumor types, allowing a measu...

journal_title：Pituitary

authors： Asa SL,Ezzat S

更新日期：2002-01-01 00:00:00

abstract：:Most patients with acromegaly have some degree of insulin resistance. The principal mediator of insulin resistance in acromegaly is hypersecretion of growth hormone. Growth hormone acts at several levels to block insulin actions including inhibiting phosphorylation of the insulin receptor and one of its principal sign...

journal_title：Pituitary

authors： Clemmons DR

更新日期：2002-01-01 00:00:00

abstract：:Pituitary cysts are usually craniopharyngiomas or remnants of Rathke's cleft. Histologically craniopharyngiomas are lined by stratified squamous epithelium whereas Rathke's cleft cysts are lined by cuboidal or columnar epithelium. The management of pituitary cysts remains difficult because of the risks associated with...

journal_title：Pituitary

authors： Dashora U,Mathias D,James A,Zammit-Maempel I,Perros P

更新日期：2002-01-01 00:00:00

abstract：:Isolated familial somatotropinomas (IFS) rarely occurs in the absence of multiple endocrine neoplasia type I (MEN1) or the Carney complex. In the present study we report two Italian siblings affected by GH-secreting adenomas. There was no history of parental consanguinity. The sister presented at 18 years of age with ...

journal_title：Pituitary

authors： De Menis E,Prezant TR

更新日期：2002-01-01 00:00:00

abstract：:A diabetic acromegalic man, not cured after surgery and radiosurgery, received lanreotide i.m. with great clinical and biochemical improvement. He required NPH insulin (76 to 84 units/day) to control his diabetes mellitus. Thirty-six hours after changing to LAR-octreotide (20 mg i.m/month) he presented symptomatic hyp...

journal_title：Pituitary

authors： Webb SM,Ortega E,Rodríguez-Espinosa J,Mato ME,Corcoy R

更新日期：2001-09-01 00:00:00

abstract：OBJECTIVE:The purpose of this study was to define safety and efficacy of medical therapy in the treatment of nonfunctioning pituitary tumours. DESIGN:We studied thirteen patients with a clinically nonfunctioning pituitary macroadenoma for response to cabergoline treatment for 1 year. Twelve/13 patients were already op...

journal_title：Pituitary

authors： Lohmann T,Trantakis C,Biesold M,Prothmann S,Guenzel S,Schober R,Paschke R

更新日期：2001-08-01 00:00:00

abstract：:Although leptin was originally viewed as an antiobesity hormone, it is now evident that it may have more pleiotropic actions. Experiments in rodents have shown that leptin activates the sympathetic nervous system, is involved in regulation of blood pressure, hematopoiesis, immune function, angiogenesis and brain, bone...

journal_title：Pituitary

authors： Popovic V,Damjanovic S,Dieguez C,Casanueva FF

更新日期：2001-01-01 00:00:00

abstract：:We report a case of hepatolithiasis (intrahepatic stone) complicated by gram-negative sepsis in a 37 year old male with acromegaly being treated with octreotide. As a child, he had suffered a traumatic injury to his liver requiring the surgical repair of a laceration. This is the first reported case of hepatolithiasis...

journal_title：Pituitary

authors： Sheehan MT,Nippoldt TB

更新日期：2000-12-01 00:00:00

abstract：:Double pituitary adenomas are rare in surgical specimens and the most common clinical feature in reported patients has been acromegaly. We report 3 cases of double pituitary lesions in patients who presented with Cushing's disease. In a 22-year-old man (case 1) with delayed puberty and low testosterone levels, mild hy...

journal_title：Pituitary

authors： Meij BP,Lopes MB,Vance ML,Thorner MO,Laws ER Jr

更新日期：2000-11-01 00:00:00

abstract：:The modern views on the anatomical and physiological interactions between the hypothalamus, pituitary and thyroid gland have emerged only in the last fifty years, although their historical roots may be found in a number of ancient and still not widely known ideas and observations. The regulation of energy body stores ...

journal_title：Pituitary

authors： Toni R

更新日期：2000-10-01 00:00:00

abstract：:We report the case of a B-cell type pituitary lymphoma in a 65 year-old male immunocompetent patient who presented with hypogonadotropic hypogonadism and central hypothyroidism and subsequently developed pulmonary lymphoma. Only three cases of pituitary lymphoma have been previously reported, one in a patient with acq...

journal_title：Pituitary

authors： Mathiasen RA,Jarrahy R,Cha ST,Kovacs K,Herman VS,Ginsberg E,Shahinian HK

更新日期：2000-05-01 00:00:00

abstract：:Acromegaly is a consequence of chronic growth hormone (GH) excess, due in the majority of cases to a GH-secreting pituitary adenoma, and occurring with a population prevalence of 60 per million and an incidence of 3-4 per million per year. Males and females appear to be equally affected with an average age of presenta...

journal_title：Pituitary

authors： Holdaway IM,Rajasoorya C

更新日期：1999-06-01 00:00:00

abstract：:160 clinically non-secreting pituitary adenomas were examined in regard to their expression of the markers PCNA, bcl2, Ki 67 in the mib-1 modification and p53 which are still under investigation for their relevance to cell proliferation. The series contained 60 null cell adenomas, 60 oncocytomas and 40 gonadotroph ade...

journal_title：Pituitary

authors： Schreiber S,Saeger W,Lüdecke DK

更新日期：1999-05-01 00:00:00

abstract：:A 57-year-old woman presented with 2-year history of polyuria and polydipsia. Hormonal studies revealed almost normal anterior pituitary function and central diabetes insipidus. Magnetic resonance imaging showed thickening of the pituitary stalk and enlargement of the neurohypophysis without high intensity of the post...

journal_title：Pituitary

authors： Waki K,Yamada S,Ozawa Y,Seki K,Endo Y

更新日期：1999-05-01 00:00:00

abstract：:A 54-years-old woman diagnosed of myotonic dystrophy (MyD) with past medical history of massive postpartum haemorrhage at age 28 and panhypopituitarism was studied. BMI and body composition were determined and we determined baseline serum IGF-I, IGFBP3, insulin and leptin levels and after the IGF-I generation test per...

journal_title：Pituitary

authors： Gómez JM,Martínez-Matos JA

更新日期：1999-01-01 00:00:00

abstract：:Cis-unsaturated free fatty acids (FFA) like oleic acid are strong blockers of both basal and stimulated GH secretion in vivo by acting directly on the somatotroph cell. Several lines of evidence suggest that this inhibitory action is the result of a perturbation of the function of several plasma membrane integral prot...

journal_title：Pituitary

authors： Pérez FR,Camiña JP,Menéndez C,Beiras A,Casabiell X,Casanueva FF

更新日期：1998-04-01 00:00:00